Decrease in sensitisation rate and intestinal anaphylactic response after nitric oxide synthase inhibition in a food hypersensitivity model.

@article{Fargeas1996DecreaseIS,
  title={Decrease in sensitisation rate and intestinal anaphylactic response after nitric oxide synthase inhibition in a food hypersensitivity model.},
  author={M J Fargeas and Vassilia Th{\'e}odorou and B Weirich and Jean Fioramonti and Lionel Bu{\'e}no},
  journal={Gut},
  year={1996},
  volume={38 4},
  pages={598-602}
}
BACKGROUND Although nitric oxide (NO) has been found to have a role in gut inflammation and to modulate immunoglobulin production, little is known about its part in food hypersensitivities. AIM This study aimed to evaluate the role of NO through the inhibition of constitutive and inducible NO synthase (cNOS and iNOS respectively) on the sensitisation process (antibody titres) and on intestinal anaphylactic responses (colonic hypersecretion upon antigen challenge). ANIMALS AND METHODS Guinea… CONTINUE READING
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