Decrease in mitochondrial complex I activity in ischemic/reperfused rat heart: involvement of reactive oxygen species and cardiolipin.

@article{Paradies2004DecreaseIM,
  title={Decrease in mitochondrial complex I activity in ischemic/reperfused rat heart: involvement of reactive oxygen species and cardiolipin.},
  author={Giuseppe Paradies and Giuseppe Petrosillo and Marilva Pistolese and Nicola Di Venosa and Antonio Federici and Francesca Maria Ruggiero},
  journal={Circulation research},
  year={2004},
  volume={94 1},
  pages={
          53-9
        }
}
Reactive oxygen species (ROS) are considered an important factor in ischemia/reperfusion injury to cardiac myocytes. Mitochondrial respiration is an important source of ROS production and hence a potential contributor to cardiac reperfusion injury. In this study, we have examined the effect of ischemia and ischemia followed by reperfusion of rat hearts on various parameters related to mitochondrial function, such as complex I activity, oxygen consumption, ROS production, and cardiolipin content… CONTINUE READING

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Evidence that Figure 7. Schematic diagram of the role of ROS and cardiolipin in mitochondrial dysfunction associated with heart ischemia/reperfusion

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