Decrease in maximal sodium permeability and slow sodium inactivation produced by trimecaine in the Ranvier node


The action of trimecaine on sodium permeability of the membrane was studied by the voltage clamp method in single nodes of Ranvier. Like procaine, trimecaine was shown to reduce maximal sodium permeability ( $$\bar P$$ Na) and to induce slow sodium inactivation. The slow inactivation arising in the presence of trimecaine was qualitatively very similar to… (More)
DOI: 10.1007/BF01063378


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