Decrease in liver collagen accumulation in carbon tetrachloride-injured and normal growing rats upon administration of zinc.

@article{Anttinen1984DecreaseIL,
  title={Decrease in liver collagen accumulation in carbon tetrachloride-injured and normal growing rats upon administration of zinc.},
  author={Henrik Anttinen and Lasse Ryh{\"a}nen and Ulla S Puistola and A. J. Arranto and Aarne Oikarinen},
  journal={Gastroenterology},
  year={1984},
  volume={86 3},
  pages={532-9}
}
Several attempts have been made to develop antifibrotic drugs for human use, but their success has been limited. The present data suggest that peroral zinc treatment has a direct and selective inhibitory effect on carbon tetrachloride-induced collagen accumulation in rat liver. Zinc did not normalize the carbon tetrachloride-induced increases in either liver relative weight, liver total protein content, fat accumulation, or the standard liver function tests, but it did efficiently inhibit liver… CONTINUE READING

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