Decrease in glial glutamate transporter variants and excitatory amino acid receptor down-regulation in a murine model of ALS-PDC

@article{Wilson2003DecreaseIG,
  title={Decrease in glial glutamate transporter variants and excitatory amino acid receptor down-regulation in a murine model of ALS-PDC},
  author={Jason M. B. Wilson and Iraj Khabazian and David V. Pow and Ulla K. Craig and Christopher A. Shaw},
  journal={NeuroMolecular Medicine},
  year={2003},
  volume={3},
  pages={105-117}
}
Glutamate transporter proteins appear crucial to controlling levels of glutamate in the central nervous system (CNS). Abnormal and/or decreased levels of various transporters have been observed in amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease (AD) and in other neurological disorders. We have assessed glutamate transporter (GLT-1/EAAT2) levels in mice fed washed cycad flour containing a suspected neurotoxin that induces features resembling the Guamanian disorder, ALS-PDC. Down… CONTINUE READING
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