Decrease in genu of the corpus callosum in medication-naïve, early-onset dysthymia and depressive personality disorder

@article{Lyoo2002DecreaseIG,
  title={Decrease in genu of the corpus callosum in medication-na{\"i}ve, early-onset dysthymia and depressive personality disorder},
  author={In Kyoon Lyoo and Jun Soo Kwon and Soo Jin Lee and Moon Hee Han and Chang Chang and Cheon Seok Seo and Sang I.k Lee and Perry F. Renshaw},
  journal={Biological Psychiatry},
  year={2002},
  volume={52},
  pages={1134-1143}
}
BACKGROUND The purpose of this study was to detect differences in regional areas of the corpus callosum (CC) in subjects with early-onset minor depression (dysthymia or depressive personality disorder) and healthy comparison subjects. Based on previous reports that have suggested reduced frontal lobe volume and reduced hemispheric lateralization in the frontal regions of the brain in depression, we hypothesized that the area of the CC that interconnects the frontal regions of the brain, i.e… Expand
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TLDR
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TLDR
These findings provide additional evidence of abnormalities in the genu of the corpus callosum in early onset depression that persist into adulthood. Expand
Corpus callosum size and shape in individuals with current and past depression.
TLDR
The corpus callosum shows expansions in regions connecting frontal, temporal and parietal regions in currently depressed patients only, suggestive of state-related changes in white matter in major depression that may reflect the effects of state -related factors on white matter structure. Expand
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TLDR
It is suggested that CC structural changes may underlie the functional impairments, frequently reported in schizophrenia, of the associated cortical regions and a negative correlation was found between CC rostrum area and the estimated lifetime neuroleptic consumption. Expand
Atrophic Corpus Callosum Associated with Altered Functional Asymmetry in Major Depressive Disorder
TLDR
Findings provide robust evidence that intra- and inter-hemispheric disconnections are involved in MDD, and that functional disruptions in the left hemisphere may be more relevant to the pathophysiology of MDD. Expand
MRI study of corpus callosum in patients with borderline personality disorder A pilot study
TLDR
Abnormalities in interhemispheric connectivity do not appear necessary for the development of BPD, and further studies with larger samples are needed to confirm this preliminary finding. Expand
The specificity of morphological changes of the corpus callosum in schizophrenia and related major mental disorders
Schizophrenia is a disabling major mental illness associated with marked impairments in reality testing, organization of speech and behaviour and cognition. Significant evidence points to functionalExpand
Corpus Callosum Size Is Highly Heritable in Humans, and May Reflect Distinct Genetic Influences on Ventral and Rostral Regions
TLDR
Distinct genetic factors seem to be involved in caudal and rostral regions, consistent with the divergent functional specialization of these brain areas. Expand
Corpus callosum size may predict late-life depression in women: a 10-year follow-up study.
TLDR
Smaller CC size is a predictive factor of incident LLD over 10 years in elderly women independently of cognitive deterioration, suggesting a possible role of CC and reduced interhemispheric connectivity in LLD pathophysiology. Expand
Shape and Volumetric Differences in the Corpus Callosum between Patients with Major Depressive Disorder and Healthy Controls
TLDR
Findings support that major depressive disorder may be due to disturbances in multiple neuronal circuits, especially those associated with the corpus callosum. Expand
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