Decrease in genu of the corpus callosum in medication-naïve, early-onset dysthymia and depressive personality disorder

  title={Decrease in genu of the corpus callosum in medication-na{\"i}ve, early-onset dysthymia and depressive personality disorder},
  author={In Kyoon Lyoo and Jun Soo Kwon and Soo Jin Lee and Moon Hee Han and Chang Chang and Cheon Seok Seo and Sang Kun Lee and Perry F. Renshaw},
  journal={Biological Psychiatry},
Age of onset and corpus callosal morphology in major depression.
Corpus callosum size and shape in individuals with current and past depression.
Corpus callosum abnormalities and potential age effect in men with schizophrenia: An MRI comparative study
Atrophic Corpus Callosum Associated with Altered Functional Asymmetry in Major Depressive Disorder
Findings provide robust evidence that intra- and inter-hemispheric disconnections are involved in MDD, and that functional disruptions in the left hemisphere may be more relevant to the pathophysiology of MDD.
MRI study of corpus callosum in patients with borderline personality disorder A pilot study
The specificity of morphological changes of the corpus callosum in schizophrenia and related major mental disorders
The results suggest that patients with schizophrenia-illness show specific thickness reductions at the level of the anterior callosum, connecting frontal cortical regions, that are present during the pre-psychotic phase and with first-episode illness.
Corpus Callosum Size Is Highly Heritable in Humans, and May Reflect Distinct Genetic Influences on Ventral and Rostral Regions
Distinct genetic factors seem to be involved in caudal and rostral regions, consistent with the divergent functional specialization of these brain areas.
Corpus callosum size may predict late-life depression in women: a 10-year follow-up study.
Shape and Volumetric Differences in the Corpus Callosum between Patients with Major Depressive Disorder and Healthy Controls
Findings support that major depressive disorder may be due to disturbances in multiple neuronal circuits, especially those associated with the corpus callosum.


Decrease in thalamic volumes of pediatric patients with obsessive-compulsive disorder who are taking paroxetine.
Thalamic volumes were significantly greater in treatment-naive patients with OCD than in controls but declined significantly after paroxetine monotherapy to levels comparable with those of controls, and decrease in OCD symptoms was associated with reduction in OCD symptom severity.
Corpus callosum size in schizophrenia – a magnetic resonance imaging analysis
In vivo magnetic resonance imaging investigated whether the midsagittal area of CC differs between right-handed male schizophrenic patients and matched controls and found no correlation between CC morphology and clinical variables such as age of onset, length of illness or symptom severity.
Chronic, low-grade depression in a nonclinical sample: depressive personality or dysthymia?
The results suggest that although DPD is not synonymous with Dysthymia, it may be a milder subtype.