Decrease in density of INa is in the common final pathway to heart block in murine hearts overexpressing calcineurin.

@article{Guo2006DecreaseID,
  title={Decrease in density of INa is in the common final pathway to heart block in murine hearts overexpressing calcineurin.},
  author={Jiqing Guo and Shan Shan Zhan and Joseph H Somers and Ruth E. Westenbroek and William A. Catterall and Dan Roach and Robert Stanley Sheldon and James P. Lees-Miller and Ping Li and Yakhin Shimoni and Henry J. Duff},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2006},
  volume={291 6},
  pages={H2669-79}
}
Overexpression of calcineurin in transgenic mouse heart results in massive cardiac hypertrophy followed by sudden death. Sudden deaths are caused by abrupt transitions from sinus rhythm to heart block (asystole) in calcineurin-overexpressing (CN) mice. Preliminary studies showed decreased maximum change in potential over time (dV/dt(max)) of phase 0 of the action potential. Accordingly, the hypothesis was tested that decreased activity of the sodium channel contributes to heart block. Profound… CONTINUE READING

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