Decrease in cortisol reverses human hippocampal atrophy following treatment of Cushing’s disease

@article{Starkman1999DecreaseIC,
  title={Decrease in cortisol reverses human hippocampal atrophy following treatment of Cushing’s disease},
  author={M. Starkman and B. Giordani and S. Gebarski and S. Berent and D. Schteingart},
  journal={Biological Psychiatry},
  year={1999},
  volume={46},
  pages={1595-1602}
}
BACKGROUND Decreased hippocampal volume is observed in patients with Cushing's syndrome and other conditions associated with elevated cortisol levels, stress, or both. Reversibility of hippocampal neuronal atrophy resulting from stress occurs in animals. Our study investigated the potential for reversibility of human hippocampal atrophy. METHODS The study included 22 patients with Cushing's disease. Magnetic resonance brain imaging was performed prior to transsphenoidal microadenomectomy and… Expand
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References

SHOWING 1-10 OF 29 REFERENCES
Hippocampal formation volume, memory dysfunction, and cortisol levels in patients with Cushing's syndrome
  • 792
  • PDF
MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder.
  • 1,373
Cortisol reduces hippocampal glucose metabolism in normal elderly, but not in Alzheimer's disease.
  • 175
  • PDF
Possible mechanisms for atrophy of the human hippocampus
  • B. McEwen
  • Psychology, Medicine
  • Molecular Psychiatry
  • 1997
  • 227
  • PDF
Long-term adrenalectomy causes loss of dentate gyrus and pyramidal neurons in the adult hippocampus
  • 102
Hippocampal damage associated with prolonged and fatal stress in primates
  • 740
  • PDF
Hippocampal atrophy in recurrent major depression.
  • 1,759
  • PDF
Effects of steroids on behavior, electrophysiology, water content and intracranial pressure in cerebral cytotoxic edema
  • H. James
  • Medicine
  • Pharmacology Biochemistry and Behavior
  • 1978
  • 7
Frequency of hippocampal formation atrophy in normal aging and Alzheimer's disease
  • 370
...
1
2
3
...