• DOI:10.1016/S0006-3223(99)00203-6
Corpus ID: 7294913

Decrease in cortisol reverses human hippocampal atrophy following treatment of Cushing’s disease

@article{Starkman1999DecreaseIC,
  title={Decrease in cortisol reverses human hippocampal atrophy following treatment of Cushing’s disease},
  author={M. Starkman and B. Giordani and S. Gebarski and S. Berent and D. Schteingart},
  journal={Biological Psychiatry},
  year={1999},
  volume={46},
  pages={1595-1602}
}

• M. Starkman, B. Giordani, +2 authors D. Schteingart
• Published 1999
• Medicine
• Biological Psychiatry

BACKGROUND Decreased hippocampal volume is observed in patients with Cushing's syndrome and other conditions associated with elevated cortisol levels, stress, or both. Reversibility of hippocampal neuronal atrophy resulting from stress occurs in animals. Our study investigated the potential for reversibility of human hippocampal atrophy. METHODS The study included 22 patients with Cushing's disease. Magnetic resonance brain imaging was performed prior to transsphenoidal microadenomectomy and… Expand

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