Decrease in cortisol reverses human hippocampal atrophy following treatment of Cushing’s disease
@article{Starkman1999DecreaseIC, title={Decrease in cortisol reverses human hippocampal atrophy following treatment of Cushing’s disease}, author={Monica N. Starkman and Bruno Giordani and Stephen S. Gebarski and Stanley Berent and M. Anthony Schork and David E. Schteingart}, journal={Biological Psychiatry}, year={1999}, volume={46}, pages={1595-1602} }
448 Citations
Improvement in learning associated with increase in hippocampal formation volume
- Psychology, MedicineBiological Psychiatry
- 2003
Loss of brain volume in endogenous Cushing's syndrome and its reversibility after correction of hypercortisolism.
- Medicine, BiologyThe Journal of clinical endocrinology and metabolism
- 2002
It is concluded that brain volume loss is highly prevalent in CS and is at least partially reversible following correction of hypercortisolism.
Reversal or continuation of hypercortisolemic effects on subregions of the hippocampus associated with treatment response in Cushing’s disease
- Medicine
- 2015
This study indicates that only a few additional months of cortisol dysregulation resulting from unsuccessful surgical treatment results in continued HPF atrophy, and that the hypercortisolemiainduced HPF atrocphy may take up to one year to reverse after successful treatment.
Cushing's Disease: a model for stress-related neuropsychiatric disorders? New evidences from MRI volumetric data
- Psychology, Biology
- 2008
Cushing's disease provides a unique opportunity to study the potential role of cortisol in the well documented structural alterations of CNS in humans, and the relationship of various brain structure's volumes with the degree of HPA hyperactivity is studied.
Elevated Cortisol Levels in Cushing’s Disease Are Associated With Cognitive Decrements
- Psychology, MedicinePsychosomatic medicine
- 2001
The results suggest that both the neocortex and hippocampus are affected in patients with Cushing’s disease, andVerbal learning and other verbal functions seem more vulnerable than nonverbal functions.
Children experience cognitive decline despite reversal of brain atrophy one year after resolution of Cushing syndrome.
- Medicine, PsychologyThe Journal of clinical endocrinology and metabolism
- 2005
Despite rapid reversibility of cerebral atrophy, children experience a significant decline in cognitive function 1 yr after correction of hypercortisolism and the effect of glucocorticoid excess on the brain of children appears to be different from adults.
Persistent cognitive impairment following surgical treatment of Cushing's syndrome
- Psychology, BiologyPsychoneuroendocrinology
- 2002
Cushing's syndrome causes irreversible effects on the human brain: a systematic review of structural and functional magnetic resonance imaging studies
- Medicine, Biology
- 2015
Patients with active CS demonstrate brain abnormalities, which only partly recover after biochemical cure, because these still occur even after long-term remission, according to this systematic review of publications evaluating brain characteristics in patients with CS using magnetic resonance imaging (MRI).
Improvement in mood and ideation associated with increase in right caudate volume.
- Psychology, MedicineJournal of affective disorders
- 2007
Depression and Anxiety Scores Are Associated with Amygdala Volume in Cushing's Syndrome: Preliminary Study
- Psychology, MedicineBioMed research international
- 2017
Patients with active CS have a smaller right amygdala volume in comparison to controls, while left amygdala volumes are associated with mood state in both patient groups.
References
SHOWING 1-10 OF 29 REFERENCES
Hippocampal formation volume, memory dysfunction, and cortisol levels in patients with Cushing's syndrome
- Biology, PsychologyBiological Psychiatry
- 1992
MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder.
- Psychology, BiologyThe American journal of psychiatry
- 1995
A smaller right hippocampal volume in PTSD that is associated with functional deficits in verbal memory is consistent with high levels of cortisol associated with stress.
Cortisol reduces hippocampal glucose metabolism in normal elderly, but not in Alzheimer's disease.
- Biology, MedicineThe Journal of clinical endocrinology and metabolism
- 1997
The interpretation is offered that glucocorticoid-mediated regulation of glucose transport is altered in AD, and this may underlie both the hippocampal insensitivity to cortisol and the failure in these patients to mount a peripheral glucose response.
Possible mechanisms for atrophy of the human hippocampus
- Biology, PsychologyMolecular Psychiatry
- 1997
The finding of hippocampal atrophy does not necessarily imply a permanent loss of cells, and this aspect deserves careful investigation, both to analyze the underlying anatomical changes and to investigate the possibility of pharmacological treatment to reverse the process.
Long-term adrenalectomy causes loss of dentate gyrus and pyramidal neurons in the adult hippocampus
- BiologyExperimental Neurology
- 1991
Hippocampal damage associated with prolonged and fatal stress in primates
- BiologyThe Journal of neuroscience : the official journal of the Society for Neuroscience
- 1989
Sustained exposure to glucocorticoids (GCs), adrenal hormones secreted during stress, can cause neural degeneration in the rat. This is particularly so in the hippocampus, a principal neural target…
Hippocampal atrophy in recurrent major depression.
- Psychology, BiologyProceedings of the National Academy of Sciences of the United States of America
- 1996
The results suggest that depression is associated with hippocampal atrophy, perhaps due to a progressive process mediated by glucocorticoid neurotoxicity.
Effects of steroids on behavior, electrophysiology, water content and intracranial pressure in cerebral cytotoxic edema
- MedicinePharmacology Biochemistry and Behavior
- 1978
Frequency of hippocampal formation atrophy in normal aging and Alzheimer's disease
- Psychology, MedicineNeurobiology of Aging
- 1997
High incidence of cortical atrophy of the cerebral and cerebellar hemispheres in Cushing's disease.
- Biology, MedicineRadiology
- 1971
A study of 31 cases of Cushing's disease shows a high degree of cerebral and cerebellar cortical atrophy in this disease, and catabolism of protein results in protein depletion.