Decrease in beta-subunit phosphotyrosine correlates with internalization and activation of the endosomal insulin receptor kinase.

@article{Burgess1992DecreaseIB,
  title={Decrease in beta-subunit phosphotyrosine correlates with internalization and activation of the endosomal insulin receptor kinase.},
  author={Jonah Burgess and Ikuo Wada and Nicholas C. Ling and Mohammad Nasir Khan and John J. M. Bergeron and Barry I. Posner},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 14},
  pages={
          10077-86
        }
}
In a previous study, we showed that the rat hepatic insulin receptor (IR) kinase of endosomes (ENs) was transiently activated to levels exceeding those of plasma membrane (PM) receptors following insulin injection. Phosphatase treatment of EN receptors abolished IR kinase activation implicating beta-subunit autophosphorylation as a mediator of the activation process (Khan, M. N., Baquiran, G., Brule, C., Burgess, J., Foster, B., Bergeron, J. J. M., and Posner, B. I. (1989) J. Biol. Chem. 264… CONTINUE READING

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 26 CITATIONS

Similar Papers

Loading similar papers…