Decrease in Reactive Amino Groups during Oxidation or Endothelial Cell Modification of LDL Correlation with Changes in Receptor-Mediated Cataboiism

@inproceedings{Steinbrecher2005DecreaseIR,
  title={Decrease in Reactive Amino Groups during Oxidation or Endothelial Cell Modification of LDL Correlation with Changes in Receptor-Mediated Cataboiism},
  author={Urs P. Steinbrecher and Joseph L. Witztum and Sampath Parthasarathy and Daniel Steinberg},
  year={2005}
}
The monocyte/macrophage appears to be the precursor of many of the lipid-laden cells in atherosclerotic lesions, but the mechanism by which these cells accumulate cholesterol to become foam cells remains unclear. We have previously reported that cultured endothelial cells can modify low density lipoprotein (LDL) in a manner that leads to rapid uptake by the… CONTINUE READING