Decrease in N-acetylaspartate/creatine ratio in the motor area and the frontal lobe in amyotrophic lateral sclerosis

@article{Abe2001DecreaseIN,
  title={Decrease in N-acetylaspartate/creatine ratio in the motor area and the frontal lobe in amyotrophic lateral sclerosis},
  author={Koichiro Abe and Mayako Takanashi and Yoshiyuki Watanabe and Hisashi Tanaka and Norihiko Fujita and Norio Hirabuki and Takehiko Yanagihara},
  journal={Neuroradiology},
  year={2001},
  volume={43},
  pages={537-541}
}
We studied whether N-acetylaspartate (NAA), a neuronal marker, is reduced in the brain of 14 patients with clinically definite amyotrophic lateral sclerosis (ALS) and whether NAA levels in the motor area and frontal lobe correlate with the clinical features, including frontal lobe function. We also studied 14 normal controls were evaluated. We obtained peak integrals in 1H magnetic resonance spectroscopy (MRS) for NAA, creatine (Cr), and choline-containing compounds (Cho). Severity of the… CONTINUE READING

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