Decrease in Mitochondrial Complex I Activity in Ischemic/Reperfused Rat Heart: Involvement of Reactive Oxygen Species and Cardiolipin

@article{Paradies2004DecreaseIM,
  title={Decrease in Mitochondrial Complex I Activity in Ischemic/Reperfused Rat Heart: Involvement of Reactive Oxygen Species and Cardiolipin},
  author={G. Paradies and G. Petrosillo and M. Pistolese and N. Di Venosa and A. Federici and F. Ruggiero},
  journal={Circulation Research: Journal of the American Heart Association},
  year={2004},
  volume={94},
  pages={53-59}
}
  • G. Paradies, G. Petrosillo, +3 authors F. Ruggiero
  • Published 2004
  • Biology, Medicine
  • Circulation Research: Journal of the American Heart Association
  • Abstract— Reactive oxygen species (ROS) are considered an important factor in ischemia/reperfusion injury to cardiac myocytes. Mitochondrial respiration is an important source of ROS production and hence a potential contributor to cardiac reperfusion injury. In this study, we have examined the effect of ischemia and ischemia followed by reperfusion of rat hearts on various parameters related to mitochondrial function, such as complex I activity, oxygen consumption, ROS production, and… CONTINUE READING
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