Decrease and dysfunction of dendritic cells correlate with impaired hepatitis C virus-specific CD4+ T-cell proliferation in patients with hepatitis C virus infection.

@article{Bella2007DecreaseAD,
  title={Decrease and dysfunction of dendritic cells correlate with impaired hepatitis C virus-specific CD4+ T-cell proliferation in patients with hepatitis C virus infection.},
  author={Silvia Della Bella and Andrea Crosignani and Antonio Riva and Pietro Presicce and Alberto Benetti and Renato Longhi and Mauro Podda and Maria Luisa Villa},
  journal={Immunology},
  year={2007},
  volume={121 2},
  pages={283-92}
}
Through the production of stimulatory and suppressive cytokines, dendritic cells (DCs) regulate virus-specific immune responses that are crucial to virus eradication. To explore a possible role of DCs in the persistence of hepatitis C virus (HCV) infection, in this study we analysed peripheral blood DCs (PBDCs) in patients with chronic hepatitis C (CHC) compared with those in both healthy seronegative (HSN) controls and a group of subjects who had spontaneously resolved infection, defined as… CONTINUE READING