Decoy strategy targeting the brain-derived neurotrophic factor exon I to attenuate tactile allodynia in the neuropathic pain model of rats.

@article{Obata2011DecoyST,
  title={Decoy strategy targeting the brain-derived neurotrophic factor exon I to attenuate tactile allodynia in the neuropathic pain model of rats.},
  author={Norihiko Obata and Satoshi Mizobuchi and Yoshitaro Itano and Yoshikazu Matsuoka and Ryuji Kaku and Naoto Tomotsuka and Kiyoshi Morita and Hirotaka Kanzaki and Mamoru Ouchida and Masataka Yokoyama},
  journal={Biochemical and biophysical research communications},
  year={2011},
  volume={408 1},
  pages={139-44}
}
The mechanism underlying neuropathic pain is still largely unclear. Recently, much attention has been focused on the role of brain-derived neurotrophic factor (BDNF) as a neuromodulator in the spinal cord. We previously reported that the expression of Bdnf exon I mRNA was remarkably up-regulated in the dorsal root ganglion (DRG) neurons with the rat L5 spinal nerve ligation (SNL) model. In the present study, we investigated whether neuropathic pain response would be reduced by the inhibition of… CONTINUE READING