Decoy receptor 3 is highly expressed in patients with rheumatoid arthritis.

@article{Hayashi2010DecoyR3,
  title={Decoy receptor 3 is highly expressed in patients with rheumatoid arthritis.},
  author={Shinya Hayashi and Yasushi Miura and Koji Tateishi and Masayasu Takahashi and Masahiro Kurosaka},
  journal={Modern rheumatology},
  year={2010},
  volume={20 1},
  pages={63-8}
}
Decoy receptor 3 (DcR3), a member of the tumor necrosis factor receptor (TNFR) superfamily, is a soluble receptor that binds to the TNF family including Fas ligand (Fas-L), LIGHT, and TL1A. DcR3 is mostly expressed in tumor cells and competitively inhibits the TNF family. We previously demonstrated that overexpressed DcR3 in rheumatoid synovial cells protects the cells from apoptosis in vitro. The objective of the study was to investigate DcR3 expression in serum and joint fluids of patients… CONTINUE READING

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