Decoy peptide targeted to Toll-IL-1R domain inhibits LPS and TLR4-active metabolite morphine-3 glucuronide sensitization of sensory neurons

Abstract

Accumulating evidence indicates that Toll-like receptor (TLR) signaling adapter protein interactions with Toll/Interleukin-1 Receptor (TIR) domains present in sensory neurons may modulate neuropathic pain states. Following ligand interaction with TLRs, TIR serves to both initiate intracellular signaling and facilitate recruitment of signaling adapter… (More)
DOI: 10.1038/s41598-017-03447-9

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Cite this paper

@inproceedings{Allette2017DecoyPT, title={Decoy peptide targeted to Toll-IL-1R domain inhibits LPS and TLR4-active metabolite morphine-3 glucuronide sensitization of sensory neurons}, author={Yohance M. Allette and Youngsook Kim and Aaron L. Randolph and Jared A. Smith and Matthew S. Ripsch and Fletcher A. White}, booktitle={Scientific reports}, year={2017} }