Decoy oligonucleotide characterization of GATA-4 transcription factor in hypertrophic agonist induced responses of cardiac myocytes

Abstract

GATA-4 transcription factor is required for normal cardiac development. However, it is unknown whether GATA-4 is an essential mediator of hypertrophic responses in the heart. Rat B-type natriuretic peptide (BNP) gene promoter contains a region of two adjacent GATA binding sites (between –68 and –97) with high affinity for GATA-4. In order to block GATA-4… (More)
DOI: 10.1007/s001090100278

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@article{Pikkarainen2002DecoyOC, title={Decoy oligonucleotide characterization of GATA-4 transcription factor in hypertrophic agonist induced responses of cardiac myocytes}, author={Sampsa Pikkarainen and Risto Kerkel{\"a} and Juhani P{\"o}ntinen and Theresa Majalahti-Palviainen and Heikki Tokola and Sinikka M Eskelinen and Olli Vuolteenaho and Heikki Ruskoaho}, journal={Journal of Molecular Medicine}, year={2002}, volume={80}, pages={51-60} }