Decoy Receptors in the Regulation of T Helper Cell Type 2 Responses

  title={Decoy Receptors in the Regulation of T Helper Cell Type 2 Responses},
  author={Andrew N. J. McKenzie and Padraic G Fallon},
  journal={The Journal of Experimental Medicine},
  pages={675 - 679}
Th2-driven responses are instrumental in disease processes including allergies, asthma, and helminth infection, and are characterized by the production of the cytokines IL-4, IL-5, IL-9, and IL-13. These cytokines form a complex network of molecular and cellular interactions that mediate protective immunity not only to worm infection, but also to induce inappropriate inflammatory responses to allergic challenge. Given the clinical importance of these molecules, considerable effort has gone into… CONTINUE READING
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