Decoupling of evolutionary changes in transcription factor binding and gene expression in mammals.

@article{Wong2015DecouplingOE,
  title={Decoupling of evolutionary changes in transcription factor binding and gene expression in mammals.},
  author={Emily S Wong and David Thybert and Bianca M Schmitt and Klara Stefflova and Duncan T. Odom and Paul Flicek},
  journal={Genome research},
  year={2015},
  volume={25 2},
  pages={167-78}
}
To understand the evolutionary dynamics between transcription factor (TF) binding and gene expression in mammals, we compared transcriptional output and the binding intensities for three tissue-specific TFs in livers from four closely related mouse species. For each transcription factor, TF-dependent genes and the TF binding sites most likely to influence mRNA expression were identified by comparing mRNA expression levels between wild-type and TF knockout mice. Independent evolution was… CONTINUE READING
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