Decoupling competing surface binding kinetics and reconfiguration of receptor footprint for ultrasensitive stress assays.

@article{Patil2015DecouplingCS,
  title={Decoupling competing surface binding kinetics and reconfiguration of receptor footprint for ultrasensitive stress assays.},
  author={Samadhan B. Patil and Manuel V{\"o}gtli and Benjamin Webb and Giuseppe Mazza and Massimo Pinzani and Y A Soh and Rachel A. McKendry and Joseph Wafula Ndieyira},
  journal={Nature nanotechnology},
  year={2015},
  volume={10 10},
  pages={
          899-907
        }
}
Cantilever arrays have been used to monitor biochemical interactions and their associated stress. However, it is often necessary to passivate the underside of the cantilever to prevent unwanted ligand adsorption, and this process requires tedious optimization. Here, we show a way to immobilize membrane receptors on nanomechanical cantilevers so that they can function without passivating the underlying surface. Using equilibrium theory, we quantitatively describe the mechanical responses of… CONTINUE READING
BETA
Tweets
This paper has been referenced on Twitter 11 times. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.

References

Publications referenced by this paper.
SHOWING 1-10 OF 40 REFERENCES

Broadly neutralizing VHH against HIV-1

  • McCoy, E L.
  • Patent application WO 2013036130 A1 (EP2753644A1,
  • 2015

Molecular evolution of broadly neutralizing llama antibodies to the CD4-binding site of HIV-1

  • McCoy, E L.
  • PLoS Pathog,
  • 2014

Rapid detection of bacterial resistance to antibiotics using AFM cantilevers as nanomechanical sensors

  • G Longo
  • Nature Nanotech
  • 2013

Llama antibodies recognizing various epitopes of the CD4bs neutralize a broad range of HIV-1 subtypes A, B, and C

  • N Strokappe
  • PLoS One,
  • 2012

Similar Papers

Loading similar papers…