Decorin-transforming growth factor- interaction regulates matrix organization and mechanical characteristics of three-dimensional collagen matrices.

@article{Ferdous2007DecorintransformingGF,
  title={Decorin-transforming growth factor- interaction regulates matrix organization and mechanical characteristics of three-dimensional collagen matrices.},
  author={Zannatul Ferdous and Victoria Mariko Wei and Renato V Iozzo and Magnus H{\"o}{\"o}k and Kathryn Jane Grande-Allen},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 49},
  pages={35887-98}
}
The small leucine-rich proteoglycan decorin has been demonstrated to be a key regulator of collagen fibrillogenesis; decorin deficiencies lead to irregularly shaped collagen fibrils and weakened material behavior in postnatal murine connective tissues. In an in vitro investigation of the contributions of decorin to tissue organization and material behavior, model tissues were engineered by seeding embryonic fibroblasts, harvested from 12.5-13.5 days gestational aged decorin null (Dcn(-/-)) or… CONTINUE READING

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