Decorin transfection suppresses profibrogenic genes and myofibroblast formation in human corneal fibroblasts.

@article{Mohan2010DecorinTS,
  title={Decorin transfection suppresses profibrogenic genes and myofibroblast formation in human corneal fibroblasts.},
  author={Rajiv R Mohan and Rangan Gupta and Maneesh K Mehan and John W. Cowden and Sunilima Sinh{\'a}},
  journal={Experimental eye research},
  year={2010},
  volume={91 2},
  pages={238-45}
}
Decorin, a small leucine-rich proteoglycan, is a natural inhibitor of transforming growth factor beta (TGFbeta). Myofibroblast and haze formation in the cornea have been attributed to TGFbeta hyperactivity released from corneal epithelium following injury to eye. This study tested the hypothesis that decorin-gene transfer inhibits TGFbeta-driven myofibroblast and haze formation in the cornea. Human corneal fibroblast (HSF) cultures generated from donor human corneas were used. Decorin cDNA was… CONTINUE READING

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