Decorin has an appetite for endothelial cell autophagy.

@article{Neill2013DecorinHA,
  title={Decorin has an appetite for endothelial cell autophagy.},
  author={Thomas Mc Neill and Annabel Mateos Torres and Simone Buraschi and Renato V Iozzo},
  journal={Autophagy},
  year={2013},
  volume={9 10},
  pages={
          1626-8
        }
}
DCN (decorin), an extracellular matrix constituent and archetypical small leucine-rich proteoglycan (SLRP), acts as a soluble tumor repressor. DCN exerts high-affinity binding interactions with receptor tyrosine kinases and evokes receptor internalization consequent with lysosomal degradation for tumorigenic and angiogenic suppression. In our recent study, we discovered that DCN evokes synthesis of PEG3 (paternally expressed 3), an imprinted gene often silenced in various forms of cancer. Upon… CONTINUE READING
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