Decorin expression is important for age-related changes in tendon structure and mechanical properties.

@article{Dunkman2013DecorinEI,
  title={Decorin expression is important for age-related changes in tendon structure and mechanical properties.},
  author={Andrew A. Dunkman and M Rebecca Buckley and Michael J. Mienaltowski and Sheila M. Adams and Stephen J Thomas and Lauren Satchell and Akash Kumar and Lydia Pathmanathan and David P. Beason and Renato V Iozzo and David E. Birk and Louis J Soslowsky},
  journal={Matrix biology : journal of the International Society for Matrix Biology},
  year={2013},
  volume={32 1},
  pages={3-13}
}
The aging population is at an increased risk of tendon injury and tendinopathy. Elucidating the molecular basis of tendon aging is crucial to understanding the age-related changes in structure and function in this vulnerable tissue. In this study, the structural and functional features of tendon aging are investigated. In addition, the roles of decorin and biglycan in the aging process were analyzed using transgenic mice at both mature and aged time points. Our hypothesis is that the increase… CONTINUE READING
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