Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis.

Abstract

Decorin inhibits the epidermal growth factor receptor (EGFR) by down-regulating its tyrosine kinase activity, thereby blocking the growth of a variety of transformed cells and tumor xenografts. In this study we provide evidence that decorin directly binds to the EGFR causing its dimerization, internalization, and ultimately its degradation. Using various… (More)

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