Decorin attenuates gliotic scar formation in the rat cerebral hemisphere.

  title={Decorin attenuates gliotic scar formation in the rat cerebral hemisphere.},
  author={Ann Logan and Abigail Baird and Martin Berry},
  journal={Experimental neurology},
  volume={159 2},
The transforming growth factor-betas (TGF-betas) are potent fibrogenic factors implicated in numerous CNS pathologies in which fibrosis and neural dysfunction are causally associated. In this study, we aimed to demonstrate significant inhibition of fibrogenesis, glial scarring, and inflammation in penetrating incisional wounds of the rat brain using the proteoglycan decorin, which effectively inhibits TGF-beta activity. Adult rats were assigned to two treatment groups each receiving 14 daily… CONTINUE READING


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