Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells.

@article{Goyal2014DecorinAA,
  title={Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells.},
  author={Atul Goyal and Thomas Mc Neill and Rick T. Owens and Liliana Schaefer and Renato V Iozzo},
  journal={Matrix biology : journal of the International Society for Matrix Biology},
  year={2014},
  volume={34},
  pages={
          46-54
        }
}
The highly conserved eukaryotic process of macroautophagy (autophagy) is a non-specific bulk-degradation program critical for maintaining proper cellular homeostasis, and for clearing aged and damaged organelles. This decision is inextricably dependent upon prevailing metabolic demands and energy requirements of the cell. Soluble monomeric decorin functions as a natural tumor repressor that antagonizes a variety of receptor tyrosine kinases. Recently, we discovered that decorin induces… CONTINUE READING
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