Decorin GAG synthesis and TGF-β signaling mediate Ox-LDL-induced mineralization of human vascular smooth muscle cells.

@article{Yan2011DecorinGS,
  title={Decorin GAG synthesis and TGF-β signaling mediate Ox-LDL-induced mineralization of human vascular smooth muscle cells.},
  author={Jianyun Yan and Sally E. Stringer and Andrew Hamilton and Valentine Charlton-Menys and Christian G{\"o}tting and Benjamin M{\"u}ller and Daniel Aeschlimann and Marie Yvonne Alexander},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2011},
  volume={31 3},
  pages={608-15}
}
OBJECTIVE Decorin and oxidized low-density lipoprotein (Ox-LDL) independently induce osteogenic differentiation of vascular smooth muscle cells (VSMCs). We aimed to determine whether decorin glycosaminoglycan (GAG) chain synthesis contributes to Ox-LDL-induced differentiation and calcification of human VSMCs in vitro. METHODS AND RESULTS Human VSMCs treated with Ox-LDL to induce oxidative stress showed increased alkaline phosphatase (ALP) activity, accelerated mineralization, and a difference… CONTINUE READING
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