Decorin, erythroblastic leukaemia viral oncogene homologue B4 and signal transducer and activator of transcription 3 regulation of semaphorin 3A in central nervous system scar tissue.

@article{Minor2011DecorinEL,
  title={Decorin, erythroblastic leukaemia viral oncogene homologue B4 and signal transducer and activator of transcription 3 regulation of semaphorin 3A in central nervous system scar tissue.},
  author={Kenneth H. Minor and Juan C Bournat and Nicole Toscano and Roman J Giger and Stephen J. A. Davies},
  journal={Brain : a journal of neurology},
  year={2011},
  volume={134 Pt 4},
  pages={
          1140-55
        }
}
Scar tissue at sites of traumatic injury in the adult central nervous system presents a combined physical and molecular impediment to axon regeneration. Of multiple known central nervous system scar associated axon growth inhibitors, semaphorin 3A has been shown to be strongly expressed by invading leptomeningeal fibroblasts. We have previously demonstrated that infusion of the small leucine-rich proteoglycan decorin results in major suppression of several growth inhibitory chondroitin sulphate… CONTINUE READING

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