Deconvolving the Recognition of DNA Shape from Sequence

  title={Deconvolving the Recognition of DNA Shape from Sequence},
  author={Namiko Abe and Iris Dror and Lin Yang and Matthew Slattery and Tianyin Zhou and Harmen J. Bussemaker and Remo Rohs and Richard S. Mann},
Protein-DNA binding is mediated by the recognition of the chemical signatures of the DNA bases and the 3D shape of the DNA molecule. Because DNA shape is a consequence of sequence, it is difficult to dissociate these modes of recognition. Here, we tease them apart in the context of Hox-DNA binding by mutating residues that, in a co-crystal structure, only recognize DNA shape. Complexes made with these mutants lose the preference to bind sequences with specific DNA shape features. Introducing… CONTINUE READING
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