Deconvolution of combinatorial libraries for drug discovery: experimental comparison of pooling strategies.

@article{WilsonLingardo1996DeconvolutionOC,
  title={Deconvolution of combinatorial libraries for drug discovery: experimental comparison of pooling strategies.},
  author={L. Wilson-Lingardo and P. W. Davis and D. Ecker and N. H{\'e}bert and O. Acevedo and K. Sprankle and T. Brennan and L. Schwarcz and S. Freier and J. Wyatt},
  journal={Journal of medicinal chemistry},
  year={1996},
  volume={39 14},
  pages={
          2720-6
        }
}
An experimental evaluation of several different pooling strategies for combinatorial libraries was conducted using a library of 810 compounds and an enzyme inhibition assay (phospholipase A2). The library contained compounds with varying degrees of activity as well as inactive compounds. The compounds were synthesized in groups of three and pooled together in various formats to realize different pooling strategies. With one exception, all iterative deconvolution strategies and position scanning… Expand
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