Deconvoluting the structural and drug-recognition complexity of the G-quadruplex-forming region upstream of the bcl-2 P1 promoter.

@article{Dexheimer2006DeconvolutingTS,
  title={Deconvoluting the structural and drug-recognition complexity of the G-quadruplex-forming region upstream of the bcl-2 P1 promoter.},
  author={Thomas S Dexheimer and Daekyu Sun and Laurence H Hurley},
  journal={Journal of the American Chemical Society},
  year={2006},
  volume={128 16},
  pages={5404-15}
}
The human bcl-2 gene contains a GC-rich region upstream of the P1 promoter that has been shown to be critically involved in the regulation of bcl-2 gene expression. We have demonstrated that the guanine-rich strand of the DNA in this region can form any one of three distinct intramolecular G-quadruplex structures. Mutation and deletion analysis permitted isolation and identification of three overlapping DNA sequences within this element that formed the three individual G-quadruplexes. Each of… CONTINUE READING

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