Deconstructing the roles of glucocorticoids in adipose tissue biology and the development of central obesity.

@article{Lee2014DeconstructingTR,
  title={Deconstructing the roles of glucocorticoids in adipose tissue biology and the development of central obesity.},
  author={M D Lee and Pornpoj Pramyothin and Kalypso Karastergiou and Susan K. Fried},
  journal={Biochimica et biophysica acta},
  year={2014},
  volume={1842 3},
  pages={473-81}
}
Central obesity is associated with insulin resistance and dyslipidemia. Thus, the mechanisms that control fat distribution and its impact on systemic metabolism have importance for understanding the risk for diabetes and cardiovascular disease. Hypercortisolemia at the systemic (Cushing's syndrome) or local levels (due to adipose-specific overproduction via 11β-hydroxysteroid dehydrogenase 1) results in the preferential expansion of central, especially visceral fat depots. At the same time… CONTINUE READING
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