Deconstructing a Disease : RAR a , Its Fusion Partners , and Their Roles in the Pathogenesis of Acute Promyelocytic Leukemia

@inproceedings{Melnick1999DeconstructingAD,
  title={Deconstructing a Disease : RAR a , Its Fusion Partners , and Their Roles in the Pathogenesis of Acute Promyelocytic Leukemia},
  author={Ari Melnick and Jonathan D Licht},
  year={1999}
}
I N THE LATE 1980s and early 1990s, the elucidation of the molecular basis of acute promyelocytic leukemia (APL) emerged as a paradigm for the connection between the bench and bedside. At that time, it became apparent that APL was, among the forms of acute myeloid leukemia, uniquely sensitive to all-transretinoic acid (ATRA)1,2 and clinical trials indicated that ATRA induced complete remissions by differentiation and eventual elimination of the malignant clone (reviewed previously3-8). In 1991… CONTINUE READING