Deconjugation of bile acids by human intestinal bacteria implanted in germ-free rats

@article{Chikai1987DeconjugationOB,
  title={Deconjugation of bile acids by human intestinal bacteria implanted in germ-free rats},
  author={Toshiyuki Chikai and Hiroyuki Nakao and Kiyohisa Uchida},
  journal={Lipids},
  year={1987},
  volume={22},
  pages={669-671}
}
Fecal bile acids in germ-free rats were analyzed after inoculation withBacteroides vulgatus, Bifidobacterium longum, Escherichia coli orClostridium ramosum. B. vulgatus preferentially deconjugated tauro-β-muricholic acid andB. longum taurocholic acid.C. ramosum deconjugated both bile acids, butE. coli deconjugated neither. 7α-Dehydroxylation of bile acids was negligible even after 18 days of inoculation, but a small amount of 7-oxo-bile acid, less than 5%, was formed. Fecal excretion of bile… CONTINUE READING
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