Decomposing the Site Frequency Spectrum: The Impact of Tree Topology on Neutrality Tests.


We investigate the dependence of the site frequency spectrum on the topological structure of genealogical trees. We show that basic population genetic statistics, for instance, estimators of θ or neutrality tests such as Tajima's D, can be decomposed into components of waiting times between coalescent events and of tree topology. Our results clarify the… (More)
DOI: 10.1534/genetics.116.188763


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