Decoding transcriptional repressor complexes in the adult central nervous system

@article{Adachi2014DecodingTR,
  title={Decoding transcriptional repressor complexes in the adult central nervous system},
  author={Megumi Adachi and Lisa M Monteggia},
  journal={Neuropharmacology},
  year={2014},
  volume={80},
  pages={45-52}
}
Cells maintain precise gene expression by balancing transcriptional activation and repression. While much work has focused on elucidating transcriptional activation in the central nervous system (CNS), little is known about transcriptional repression. One means to repress gene expression is to initiate binding of transcription factors to DNA, which then recruit co-repressors as well as other accessory proteins, forming a multi-protein repressor complex. These multi-protein repressor complexes… CONTINUE READING
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