Decoding the quantitative nature of TGF-beta/Smad signaling.

@article{Clarke2008DecodingTQ,
  title={Decoding the quantitative nature of TGF-beta/Smad signaling.},
  author={David C. Clarke and Xuedong Liu},
  journal={Trends in cell biology},
  year={2008},
  volume={18 9},
  pages={430-42}
}
How transforming growth factor-beta (TGF-beta) signaling elicits diverse cell responses remains elusive, despite the major molecular components of the pathway being known. We contend that understanding TGF-beta biology requires mathematical models to decipher the quantitative nature of TGF-beta/Smad signaling and to account for its complexity. Here, we review mathematical models of TGF-beta superfamily signaling that predict how robustness is achieved in bone-morphogenetic-protein signaling in… CONTINUE READING