Decoding the molecular design principles underlying Ca(2+) binding to βγ-crystallin motifs.

Abstract

Numerous proteins belonging to the recently expanded βγ-crystallin superfamily bind Ca(2+) at the double-clamp N/D-N/D-X(1)-X(2)-S/T-S motif. However, there have been no attempts to understand the intricacies involving Ca(2+) binding, such as the determinants of Ca(2+)-binding affinity and their contributions to gain in stability. This work is an in-depth… (More)
DOI: 10.1016/j.jmb.2011.10.037

Topics

Cite this paper

@article{Mishra2012DecodingTM, title={Decoding the molecular design principles underlying Ca(2+) binding to βγ-crystallin motifs.}, author={Amita Mishra and Shashi Kumar Suman and Shanti Swaroop Srivastava and Rajan Sankaranarayanan and Yogendra Sharma}, journal={Journal of molecular biology}, year={2012}, volume={415 1}, pages={75-91} }