Decoding the fine-scale structure of a breast cancer genome and transcriptome.

  title={Decoding the fine-scale structure of a breast cancer genome and transcriptome.},
  author={Stanislav Volik and Benjamin J. Raphael and Guiqing Huang and Michael R. Stratton and Graham Bignel and John Murnane and John H. Brebner and Krystyna Bajsarowicz and Pamela L. Paris and Quanzhou Tao and David Kowbel and Anna Lapuk and Dmitri A Shagin and Irina A. Shagina and Joe W. Gray and Jan-fang Cheng and Pieter J de Jong and Pavel A. Pevzner and Colin Collins},
  journal={Genome research},
  volume={16 3},
A comprehensive understanding of cancer is predicated upon knowledge of the structure of malignant genomes underlying its many variant forms and the molecular mechanisms giving rise to them. It is well established that solid tumor genomes accumulate a large number of genome rearrangements during tumorigenesis. End Sequence Profiling (ESP) maps and clones genome breakpoints associated with all types of genome rearrangements elucidating the structural organization of tumor genomes. Here we extend… CONTINUE READING
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