Decoding the Anti-Trypanosoma cruzi Action of HIV Peptidase Inhibitors Using Epimastigotes as a Model

@inproceedings{Sangenito2014DecodingTA,
  title={Decoding the Anti-Trypanosoma cruzi Action of HIV Peptidase Inhibitors Using Epimastigotes as a Model},
  author={Leandro Stefano Sangenito and Rubem Figueiredo Sadok Menna-Barreto and Claudia M. d′Avila-Levy and Andr{\'e} L S Santos and Marta Helena Branquinha},
  booktitle={PloS one},
  year={2014}
}
BACKGROUND Aspartic peptidase inhibitors have shown antimicrobial action against distinct microorganisms. Due to an increase in the occurrence of Chagas' disease/AIDS co-infection, we decided to explore the effects of HIV aspartic peptidase inhibitors (HIV-PIs) on Trypanosoma cruzi, the etiologic agent of Chagas' disease. METHODOLOGY AND PRINCIPAL FINDINGS HIV-PIs presented an anti-proliferative action on epimastigotes of T. cruzi clone Dm28c, with IC50 values ranging from 0.6 to 14 µM. The… CONTINUE READING
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