Decoding cytosolic Ca2+ oscillations.
@article{Parekh2011DecodingCC, title={Decoding cytosolic Ca2+ oscillations.}, author={A. Parekh}, journal={Trends in biochemical sciences}, year={2011}, volume={36 2}, pages={ 78-87 } }
A rise in cytosolic Ca(2+) concentration is used as a universal signalling mechanism to control biological processes as diverse as exocytosis, contraction, cell growth and cell death. Ca(2+) signals are often presented to cells in the form of Ca(2+) oscillations, with signalling information encoded in both amplitude and frequency of the Ca(2+) spikes. Recent studies have revealed that the sub-cellular spatial profile of the Ca(2+) oscillation is also important in activating cellular responses… CONTINUE READING
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References
SHOWING 1-10 OF 96 REFERENCES
Decoding of Cytoplasmic Ca2+ Oscillations through the Spatial Signature Drives Gene Expression
- Biology, Medicine
- Current Biology
- 2009
- 116
- PDF
Biphasic Regulation of Mitochondrial Ca2+ Uptake by Cytosolic Ca2+ Concentration
- Biology, Medicine
- Current Biology
- 2006
- 110
STIM Is a Ca2+ Sensor Essential for Ca2+-Store-Depletion-Triggered Ca2+ Influx
- Biology, Medicine
- Current Biology
- 2005
- 1,805
Ca2+ microdomains near plasma membrane Ca2+ channels: impact on cell function
- Biology, Medicine
- The Journal of physiology
- 2008
- 195
Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations.
- Biology, Medicine
- Science
- 1998
- 1,260
- PDF
Mitochondrial control of calcium-channel gating: a mechanism for sustained signaling and transcriptional activation in T lymphocytes.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 2000
- 259
- PDF
Spatial and temporal aspects of cellular calcium signaling
- Chemistry, Medicine
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology
- 1996
- 475
Calcium oscillations increase the efficiency and specificity of gene expression
- Biology, Medicine
- Nature
- 1998
- 1,887
- PDF