Decoding cytosolic Ca2+ oscillations.

@article{Parekh2011DecodingCC,
  title={Decoding cytosolic Ca2+ oscillations.},
  author={Anant B Parekh},
  journal={Trends in biochemical sciences},
  year={2011},
  volume={36 2},
  pages={
          78-87
        }
}
  • A. Parekh
  • Published 1 February 2011
  • Biology
  • Trends in biochemical sciences
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Calmodulin-controlled Spatial Decoding of Oscillatory Ca 2 + Signals by 1 Calcineurin 2 3 4
TLDR
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References

SHOWING 1-10 OF 97 REFERENCES
Store-operated calcium channels.
TLDR
The key electrophysiological features of I(CRAC) and other store-operated Ca(2+) currents and how they are regulated are described, and recent advances that have shed insight into the molecular mechanisms involved in this ubiquitous and vital Ca( 2+) entry pathway are considered.
Ca2+ microdomains near plasma membrane Ca2+ channels: impact on cell function
  • A. Parekh
  • Biology
    The Journal of physiology
  • 2008
TLDR
Basic features of Ca2+ microdomains are delineated and how these highly local signals are used by Ca2 +‐permeable channels to drive cellular responses are described.
Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations.
TLDR
Rapid superfusion of immobilized Ca2+- and calmodulin-dependent protein kinase II in vitro showed that the enzyme can decode the frequency ofCa2+ spikes into distinct amounts of kinase activity, suggesting its pivotal role in activity-dependent forms of synaptic plasticity.
Mitochondrial control of calcium-channel gating: a mechanism for sustained signaling and transcriptional activation in T lymphocytes.
TLDR
A role for mitochondria is demonstrated in controlling Ca(2+) channel activity and signal transmission from the plasma membrane to the nucleus and inhibiting nuclear translocation of the transcription factor NFAT in parallel with CRAC channel activity.
Spatial and temporal aspects of cellular calcium signaling
TLDR
The mechanisms and physi‐ological significance of this behavior in nonexcitable cells are discussed, in which the primary mechanism of Ca2+ mobilization is through (l,4,5)IP3‐dependent Ca 2+ release from intracellular stores.
Calcium oscillations increase the efficiency and specificity of gene expression
TLDR
It is reported that oscillations reduce the effective Ca2+ threshold for activating transcription factors, thereby increasing signal detection at low levels of stimulation and providing direct evidence that [Ca2+]i oscillations increase both the efficacy and the information content of Ca2+, leading to gene expression and cell differentiation.
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