Decoding complex patterns of genomic rearrangement in hepatocellular carcinoma.

  title={Decoding complex patterns of genomic rearrangement in hepatocellular carcinoma.},
  author={Julio Fernandez-Banet and Nikki P.Y. Lee and Kin Tak Chan and Huan Gao and Xiao Liu and Wing Kin Sung and Winnie Tan and Sheung Tat Fan and Ronnie Tung-ping Poon and Shiyong Li and Keith Ching and Paul A. Rejto and Mao Mao and Zhengyan Kan},
  volume={103 2-3},
Elucidating the molecular basis of hepatocellular carcinoma (HCC) is crucial to developing targeted diagnostics and therapies for this deadly disease. The landscape of somatic genomic rearrangements (GRs), which can lead to oncogenic gene fusions, remains poorly characterized in HCC. We have predicted 4314 GRs including large-scale insertions, deletions, inversions and translocations based on the whole-genome sequencing data for 88 primary HCC tumor/non-tumor tissues. We identified… CONTINUE READING
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