Declining intracellular T-lymphocyte concentration of cyclosporine a precedes acute rejection in kidney transplant recipients.


BACKGROUND We investigated cyclosporine A (CsA) concentrations at the site of action, inside T-lymphocytes, to evaluate its applicability as a new supplementary therapeutic drug monitoring method after renal transplantation. METHOD In this prospective single-center study, 20 kidney transplant recipients, mean age 54 (range 21-74) years, on CsA-based… (More)
DOI: 10.1097/TP.0b013e31815feede