Decline in osteocyte lacunar density in human cortical bone is associated with accumulation of microcracks with age.

@article{Vashishth2000DeclineIO,
  title={Decline in osteocyte lacunar density in human cortical bone is associated with accumulation of microcracks with age.},
  author={Deepak Vashishth and Olivier Verborgt and George W. Divine and Mitchell B. Schaffler and David P. Fyhrie},
  journal={Bone},
  year={2000},
  volume={26 4},
  pages={375-80}
}
Despite osteocytes' ideal position to sense the local environment and thereby influence bone remodeling, the function of osteocytes in bone remains controversial. In this study, histomorphometric examination of male and female femoral middiaphyseal cortical bone was conducted to determine if bone's remodeling response, indicated by tissue porosity and accumulation of damage, is associated with osteocyte lacunar density (number of osteocyte lacunae per bone area). The results support the sensory… CONTINUE READING

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