Decline in Prevalence of Neural Tube Defects in a High-Risk Region of the United States

@article{Stevenson2000DeclineIP,
  title={Decline in Prevalence of Neural Tube Defects in a High-Risk Region of the United States},
  author={Roger E. Stevenson and William P. Allen and Gurpur Shashidhar Pai and Robert Best and Laurie H Seaver and Jane H Dean and Shirley J. Thompson},
  journal={Pediatrics},
  year={2000},
  volume={106},
  pages={677 - 683}
}
Objectives. To conduct surveillance for neural tube defects (NTDs) in a high-risk region of the United States and to prevent occurrence and recurrence of NTDs through the periconceptional use of folic acid supplements. Design. Active and passive methods were used for surveillance of NTD-affected pregnancies and births during a 6-year period (October 1992–September 1998). Individual genetic counseling was used to prevent NTD recurrences and a public awareness campaign was used to reduce NTD… Expand
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166 Citations
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166 Citations

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Citation Type

Long term maintenance of neural tube defects prevention in a high prevalence state.
TLDR
Increased periconceptional intake of FA appeared to reduce NTDs in a high-prevalence region of the United States. Expand
Economic evaluation of a neural tube defect recurrence-prevention program.
TLDR
The South Carolina N TD recurrence-prevention program appears comparable in cost effectiveness to other preventive services, and other states might consider including NTD recurrence prevention in birth defect-pre prevention programs. Expand
Decreasing prevalence of neural tube defects in Utah, 1985-2000.
TLDR
NTDs in Utah have decreased significantly between 1985-2000 and remain at the lowest prevalence over the last three of those years, likely the result of simultaneous prevention activities locally and nationally, the Utah population's propensity for vitamin and supplement consumption, and recent food fortification. Expand
Decline of neural tube defects cases after a folic acid campaign in Nuevo León, México.
TLDR
After 2 years there was a 50% decrease in the incidence of anencephaly and spina bifida cases with a significant reduction of infant mortality and disability and these results encourage the use of a single tablet of 5.0-mg of folic acid per week as an alternative to supplementation on a daily basis. Expand
The impact of prenatal diagnosis on neural tube defect (NTD) pregnancy versus birth incidence in British Columbia
TLDR
The birth incidence of neural tube defect (NTD) cases in British Columbia, and elsewhere in North America, is reported to be declining, but second trimester prenatal screening of pregnancies for NTDs and other congenital anomalies has increased during this timeframe, as well. Expand
Bayesian Small Area Cluster Analysis of Neural Tube Defects in Newfoundland
TLDR
The implications of this observation imply that overall response to the decrease in cases tends to be uniform across the province, with potentially one area of interest where extra efforts may be devoted. Expand
Are the recommendations on the prevention of neural tube defects working?
TLDR
Recommendations alone did not influence trends in NTD in this country up to 11 years after the confirmation of the effectiveness of folic acid in clinical trials, and new strategies are needed. Expand
Survival of Infants With Neural Tube Defects in the Presence of Folic Acid Fortification
TLDR
Whether survival among infants born with spina bifida and encephalocele has improved since folic acid fortification has improved is determined and the effects of selected maternal, pregnancy, and birth characteristics on first-year (infant) survival rates are measured. Expand
Neural tube defects at Siriraj Hospital, Bangkok, Thailand--10 years review (1990-1999).
TLDR
Public health interventions aimed at increasing the periconceptional consumption of folic acid should be implemented or enhanced to reduce the incidence of NTDs in Thailand. Expand
When folic acid fails: Insights from 20 years of neural tube defect surveillance in South Carolina
TLDR
Cases in which FA failed in prevention of N TDs provide potential areas for further study into the causation of NTDs, and the measures and techniques implemented in South Carolina can serve as an effective and successful model for prevention ofNTD occurrence and recurrence. Expand
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