Decline in Prevalence of Neural Tube Defects in a High-Risk Region of the United States

@article{Stevenson2000DeclineIP,
  title={Decline in Prevalence of Neural Tube Defects in a High-Risk Region of the United States},
  author={Roger E. Stevenson and William P. Allen and Gurpur Shashidhar Pai and Robert Best and Laurie H Seaver and Jane H Dean and Shirley J. Thompson},
  journal={Pediatrics},
  year={2000},
  volume={106},
  pages={677 - 683}
}
Objectives. To conduct surveillance for neural tube defects (NTDs) in a high-risk region of the United States and to prevent occurrence and recurrence of NTDs through the periconceptional use of folic acid supplements. Design. Active and passive methods were used for surveillance of NTD-affected pregnancies and births during a 6-year period (October 1992–September 1998). Individual genetic counseling was used to prevent NTD recurrences and a public awareness campaign was used to reduce NTD… Expand
Long term maintenance of neural tube defects prevention in a high prevalence state.
TLDR
Increased periconceptional intake of FA appeared to reduce NTDs in a high-prevalence region of the United States. Expand
Economic evaluation of a neural tube defect recurrence-prevention program.
TLDR
The South Carolina N TD recurrence-prevention program appears comparable in cost effectiveness to other preventive services, and other states might consider including NTD recurrence prevention in birth defect-pre prevention programs. Expand
Decreasing prevalence of neural tube defects in Utah, 1985-2000.
TLDR
NTDs in Utah have decreased significantly between 1985-2000 and remain at the lowest prevalence over the last three of those years, likely the result of simultaneous prevention activities locally and nationally, the Utah population's propensity for vitamin and supplement consumption, and recent food fortification. Expand
Decline of neural tube defects cases after a folic acid campaign in Nuevo León, México.
TLDR
After 2 years there was a 50% decrease in the incidence of anencephaly and spina bifida cases with a significant reduction of infant mortality and disability and these results encourage the use of a single tablet of 5.0-mg of folic acid per week as an alternative to supplementation on a daily basis. Expand
The impact of prenatal diagnosis on neural tube defect (NTD) pregnancy versus birth incidence in British Columbia
TLDR
The birth incidence of neural tube defect (NTD) cases in British Columbia, and elsewhere in North America, is reported to be declining, but second trimester prenatal screening of pregnancies for NTDs and other congenital anomalies has increased during this timeframe, as well. Expand
Bayesian Small Area Cluster Analysis of Neural Tube Defects in Newfoundland
TLDR
The implications of this observation imply that overall response to the decrease in cases tends to be uniform across the province, with potentially one area of interest where extra efforts may be devoted. Expand
Are the recommendations on the prevention of neural tube defects working?
TLDR
Recommendations alone did not influence trends in NTD in this country up to 11 years after the confirmation of the effectiveness of folic acid in clinical trials, and new strategies are needed. Expand
Survival of Infants With Neural Tube Defects in the Presence of Folic Acid Fortification
TLDR
Whether survival among infants born with spina bifida and encephalocele has improved since folic acid fortification has improved is determined and the effects of selected maternal, pregnancy, and birth characteristics on first-year (infant) survival rates are measured. Expand
Neural tube defects at Siriraj Hospital, Bangkok, Thailand--10 years review (1990-1999).
TLDR
Public health interventions aimed at increasing the periconceptional consumption of folic acid should be implemented or enhanced to reduce the incidence of NTDs in Thailand. Expand
When folic acid fails: Insights from 20 years of neural tube defect surveillance in South Carolina
TLDR
Cases in which FA failed in prevention of N TDs provide potential areas for further study into the causation of NTDs, and the measures and techniques implemented in South Carolina can serve as an effective and successful model for prevention ofNTD occurrence and recurrence. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 25 REFERENCES
Prevalence of neural tube defects in northeastern France, 1979-1992 impact of prenatal diagnosis.
TLDR
Comparison with similar studies in other countries demonstrated that screening by maternal serum alpha-fetoprotein is needed in northeastern France, as the total prevalence of NTD in the region remained stable but birth prevalence fell significantly, and this decrease was obtained by routine ultrasonographic examination only and termination of pregnancy. Expand
Prevalence of neural tube defects in northeastern France, 1979-1994. Impact of prenatal diagnosis.
TLDR
Comparison with similar studies in other countries demonstrated that screening by maternal serum alpha-fetoprotein is needed in northeastern France, where the total prevalence of NTD in this region remained stable but birth prevalence fell significantly, particularly for anencephaly and spina bifida. Expand
The changing epidemiology of neural tube defects. United States, 1968-1989.
TLDR
The declining rates of neural tube defect rates can be partially explained by increased widespread prenatal diagnostic techniques, strongly suggesting the role of environmental factors in neural tube defects. Expand
Prevalence of spina bifida at birth--United States, 1983-1990: a comparison of two surveillance systems.
  • J. Lary, L. Edmonds
  • Medicine
  • MMWR. CDC surveillance summaries : Morbidity and mortality weekly report. CDC surveillance summaries
  • 1996
TLDR
In both the state-based surveillance systems and BDMP, the annual rate of spina bifida for the total population declined during the period 1983-1990, and an environmental component may have contributed substantially to the etiologies of these defects. Expand
Surveillance for anencephaly and spina bifida and the impact of prenatal diagnosis--United States, 1985-1994.
  • J. Cragan, H. Roberts, +10 authors J. Dean
  • Medicine
  • MMWR. CDC surveillance summaries : Morbidity and mortality weekly report. CDC surveillance summaries
  • 1995
TLDR
This report presents data from birth defects surveillance systems in six states over different time periods and indicates that the impact of prenatal diagnosis and subsequent pregnancy termination on the prevalence at birth of anencephaly and spina bifida differs among geographic areas and populations. Expand
THE IMPACT OF PRENATAL DIAGNOSIS ON NTD SURVEILLANCE
TLDR
Consideration of the significant impact of prenatal diagnosis on NTD surveillance and the use of multiple ascertainment methods in an attempt at complete ascertainment is particularly important now because of the recent recommendation for the periconceptional use of folic acid to prevent neural tube defects and the need for epidemiological studies to monitor the effectiveness of this prevention. Expand
Neural tube defects in Eastern Ontario and Western Quebec: demography and family data.
  • A. Hunter
  • Medicine
  • American journal of medical genetics
  • 1984
TLDR
The prevalence of neural tube defects at birth in families in the Eastern Ontario/Western Quebec region during the years 1969-1981 has fallen from previous levels, but there was no evidence of further decline during the period of study. Expand
Prevention of the First Occurrence of Neural-Tube Defects by Periconceptional Vitamin Supplementation
TLDR
A randomized, controlled trial of periconceptional multivitamin supplementation to test the efficacy of this treatment in reducing the incidence of a first occurrence of neural-tube defects. Expand
Etiologic heterogeneity of neural tube defects: clues from epidemiology.
TLDR
It is suggested that analytic studies of neural tube defects may be more rewarding if they try to identify different risk factors associated with various subgroups, which may provide better clues to their etiology and pathogenesis. Expand
Use of folic acid for prevention of spina bifida and other neural tube defects--1983-1991.
  • Medicine
  • MMWR. Morbidity and mortality weekly report
  • 1991
TLDR
Recommendations for supplementation with folic acid before conception and during early pregnancy to prevent the recurrence of neural tube defects are provided. Expand
...
1
2
3
...