Decitabine has a biphasic effect on natural killer cell viability, phenotype, and function under proliferative conditions.

Abstract

DNA hypermethylation resulting in aberrant epigenetic silencing plays an important role in the oncogenesis of many cancer types, including acute myelogenous leukemia (AML).(4) The modulation of NK cell receptors and their cognate ligands is a known mechanism of immune escape in AML, and some membrane proteins, such as killer immunoglobulin-like receptors… (More)
DOI: 10.1016/j.molimm.2012.12.012

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