Decisions, decisions: beta-catenin chooses between adhesion and transcription.

  title={Decisions, decisions: beta-catenin chooses between adhesion and transcription.},
  author={Tony J.C. Harris and Mark Peifer},
  journal={Trends in cell biology},
  volume={15 5},
beta-catenin functions in both cell adhesion and transcription. Properly choosing between these functions is crucial for normal development, and the wrong choice can lead to cancer. Recent studies have revealed molecular switches that help dictate whether beta-catenin interacts with adhesive or transcriptional complexes. Cara Gottardi and Barry Gumbiner identify Wnt-induced beta-catenin conformational changes that favor assembly into transcription complexes, whereas alpha-catenin-associated… CONTINUE READING