Decision tree–driven tandem mass spectrometry for shotgun proteomics

  title={Decision tree–driven tandem mass spectrometry for shotgun proteomics},
  author={Danielle L. Swaney and G Mcalister and Joshua J. Coon},
  journal={Nature Methods},
Mass spectrometry has become a key technology for modern large-scale protein sequencing. Tandem mass spectrometry, the process of peptide ion dissociation followed by mass-to-charge ratio (m/z) analysis, is the critical component for peptide identification. Recent advances in mass spectrometry now permit two discrete, and complementary, types of peptide ion fragmentation: collision-activated dissociation (CAD) and electron transfer dissociation (ETD) on a single instrument. To exploit this… CONTINUE READING

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