Deciphering the systems biology of mTOR inhibition by integrative transcriptome analysis.

@article{Domhan2014DecipheringTS,
  title={Deciphering the systems biology of mTOR inhibition by integrative transcriptome analysis.},
  author={Sophie Domhan and Christian Schwager and Quanxiang Wei and Stefan Muschal and Claudia Sommerer and Christian Morath and Wolfgang Wick and Christian Maercker and Jurgen Debus and Martin G. Zeier and Peter E Huber and Amir Hossein Abdollahi},
  journal={Current pharmaceutical design},
  year={2014},
  volume={20 1},
  pages={
          88-100
        }
}
The mTOR signaling plays an integral role in cellular homeostasis controlling the transition between the catabolic and anabolic states. Originally approved as immunosuppressive agents preventing allograft rejection, inhibitors of mTOR signaling have recently entered the arena of cancer therapy. Using rapamycin derivative (RAD001) as a prototype inhibitor, we aimed to systematically analyze the molecular mechanisms underlying the pleiotropic effects of mTOR signaling. Using proliferation- and… CONTINUE READING